Dot1l in hematopoiesis and leukemia
Jo, Stephanie
Disruptor of telomeric silencing 1-like (Dot1l) is a histone 3 lysine 79 methyltransferase. Constitutive Dot1l knockout mice studies show that Dot1l is essential for prenatal development and hematopoiesis. Dot1l also interacts with fusion partners of Mixed Lineage Leukemia (MLL) gene, which is commonly translocated in human leukemia. However, the requirement of Dot1l in postnatal hematopoiesis and leukemogenesis of MLL translocation proteins h...